1887

Journal of Medical Microbiology logo

Volume 68, Issue 5

Polyclonal spread of multiple genotypes of in semi-closed settings in Yamagata, Japan Free

Abstract

To clarify the spread of infections in semi-closed settings such as schools and family homes using molecular typing methods.

We retrospectively searched for school- and family-based clusters of infections based on information regarding patients from whom strains had been isolated between 2011 and 2013 in Yamagata, Japan. The molecular typing profile, including the P1 type and the four-locus (Mpn13, 14, 15 and 16) multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) type, was obtained from our previous study.

We identified 11 school-based clusters involving 71 patients and 16 family-based clusters involving 38 patients, including 14 duplications between these types of clusters. A total of 95 strains isolated from those patients were divided into 4 genotypes: 33 strains of type 4-5-7-2, 1; 31 of type 4-5-7-3, 1; 24 of type 3-5-6-2, 2c; and 7 of type 3-5-6-2, 2a. Of the 11 school-based clusters, 6 clusters (54.5%) consisted of multiple genotypes, and the remaining 5 clusters consisted of a single genotype. Moreover, the presence of multiple genotypes was identified in three classrooms of a school. On the other hand, in 14 (87.5%) of the 16 family-based clusters, the genotypes of the strains isolated from each family member were identical.

The spread of infection in schools is likely polyclonal, since strains are brought into schools from various sites, such as family homes, which are important sites of disease transmission.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): disease transmission , family infection , molecular typing , Mycoplasma pneumoniae , school epidemic and VNTR
© 2019 The Authors
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2019-05-01
2024-04-27
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Polyclonal spread of multiple genotypes of Mycoplasma pneumoniae in semi-closed settings in Yamagata, Japan
J. Med. Microbiol. 68, 785 (2019); https://doi.org/10.1099/jmm.0.000969
/content/journal/jmm/10.1099/jmm.0.000969
/content/journal/jmm/10.1099/jmm.0.000969
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